Dimethylcarbamoyl Chloride → HCID 19089098, compound

Participants

Reaction Steps

To a solution of 1H-imidazo[1,2-b]pyrazole (2 g) in tetrahydrofuran (20 ml) were added N,N-dimethylcarbamoyl chloride (3.8 ml) and triethylamine (6.2 ml) at 20° C. under stirring. After stirring, the reaction mixture was poured into a mixture of ethyl acetate (30 ml) and cold water (50 ml). The ethyl acetate layer was separated, washed with water and a saturated aqueous solution of sodium chloride, dried over magnesium sulfate and evaporated in vacuo to give 1-(N,N-dimethylcarbamoyl)-1H-imidazo[1,2-b]pyrazole (3.0 g).

Provenance & Evidence