Water → HCID 19759191, compound

Participants

Reaction Steps

A mixture of 0.80 g (0.00213 mole) of the piperidine derivative, 0.45 g (0.00427 mol) of 2-vinylpyridine, 0.435 g (0.0032 mol) of sodium acetate trihydrate, 2 mL of water and 2 mL of methanol was stirred and refluxed for 15 hours. The solution was evaporated to dryness and the residue was purified by flash chromatography on silica gel using 5% CH3OH in chloroform saturated with ammonia as an eluant. The chromatographically homogeneous fractions were combined. An oxalate salt, prepared in isopropyl alcohol-ethanol, was recrystallized from water to five the title compound, mp. 206°-208° C.

Provenance & Evidence