Hydrochloric Acid → HCID 57171953, compound

Participants

Reaction Steps

A solution of (2S,4R)-1-allyloxycarbonyl-4-tertbutyldimethylsilyloxy-2-(imidazo[1,2-b]pyrazol-1-yl)methylpyrrolidine (4.23 g) and conc. hydrochloric acid (2.61 ml) in methanol (40 ml) was stirred at ambient temperature for 5 hours. The reaction mixture was adjusted to pH 8-9 with 28% sodium methoxide in methanol solution and the mixture was concentrated in vacuo. The resulting residue was chromatographed on silica gel (100 g) eluting with a mixture of dichloromethane and acetone (2:1, V/V). The fractions containing the desired compound were collected and evaporated in vacuo to give (2S,4R)-1-allyloxycarbonyl-4-hydroxy-2-(imidazo [1,2-b]pyrazol-1-yl)methylpyrrolidine (3.18 g).

Provenance & Evidence