Methyl iodide → HCID 88466713, compound

Participants

Reaction Steps

To a solution of 4-nitrobenzyl (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-[(2S,4S)-1-(4-nitrobenzyloxycarbonyl) -2-{4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-4yl}methylpyrrolidin-4-yl]thio-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylate (0.78 g) in a mixture of acetone (8 ml) and tetrahydrofuran (16 ml) was added methyl iodide (0.64 ml) with stirring and the mixture was allowed to stand at ambient temperature overnight. The reaction mixture was evaporated in vacuo to give 4-nitrobenzyl (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-3-[(2S,4S)-1-(4-nitro benzyloxycarbonyl)-2-{1-methyl-4,5,6,7-tetrahydro-4-pyrazolo [1,5-a]primidinio}methylpyrrolidin-4yl]thio-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate iodide (0.88 g).

Provenance & Evidence