Sodium Hydroxide → HCID 53942252, compound

Participants

Reaction Steps

To a solution of 10 g of 1-[2-chloro-2-(2,4-dichlorophenyl)hexyl] imidazole in 100 ml of dimethyl sulfoxide is added 25 ml of 50% sodium hydroxide solution dropwise at room temperature. The reaction mixture is heated at 60° for 2 hours. It is then poured into 300 ml of ice water and extracted with ether. The combined ether extracts are washed with saturated sodium chloride solution and dried over magnesium sulfate. Drying agent is filered and to the filtrate is added concentrated nitric acid dropwise until it is strongly acidic. An oily material settled and is triturated with a 50--50 ether-hexane mixture three times and then back neutralized to its free base with 10% ammonium hydroxide solution. The free base is extracted with ether and the combined ether extracts are washed with water and saturated sodium chloride solution and dried over magnesium sulfate. Solvent is evaporated to give 6 g of a brown oily product.

Provenance & Evidence