反应详情

Procedure A was followed with 1-propanesulfonamide (5.0 g, 40.6 mmole), in acetone (40 ml), and 1.0N sodium hydroxide (40.6 ml). After ten minutes of stirring, 4-chlorophenyl isocyanate (6.2 g, 40.6 mmole) dissolved in about 40 ml of acetone was added over a five minute period. The mixture was allowed to stir for about two hours and filtered. The filtered solid was washed with water which dissolved most of it. 1N HCl (40 ml) was added to the combined filtrates and the resulting precipitate was filtered off and dried at about 65° C. under vacuum to provide 7.2 g of product.

1. additionwas added over a five minute period
2. stirringto stir for about two hours
3. filtrationfiltered
4. washThe filtered solid was washed with water which
5. dissolutiondissolved most of it
6. addition1N HCl (40 ml) was added to the combined filtrates
7. filtrationthe resulting precipitate was filtered off
8. customdried at about 65° C. under vacuum