Hydrochloric Acid → HCID 19759908, compound

Participants

Reaction Steps

The title compound was prepared in the same way as 5-(N-isobutylaminomethyl)4,5-dihydro-5-methylthieno[2,3-b]thiophene-2-sulfonamide-6,6-dioxide hydrochloride. Thus 5-(N-isopropylcarbamoyl)-4,5-dihydro-5-methylthieno[2,3-b]thiophene-2-N-t-butylsulfonamide-6,6-dioxide (3.0 g, 7.3 mmol) was reduced with borane-dimethylsulfide complex (5.0 mL, 50 mmol), deprotected with TFA, and converted to the HCl salt to give the title compound as a white solid (1.32 g, 48% over two steps), mp=132°-135° C. Anal. Calc. for C11H18N2O4S3.HCl.1/2H2O: C, 34.41; H, 5.25; N, 7.29. Found: C, 34.42; H, 5.19; N, 7.11.

Provenance & Evidence