HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boc-N-Me-Phe-OH → N-[N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-phenylalanyl]-3-mercapto-D-valine, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boc-N-Me-Phe-OH | HCID 7010602 | — |
| Reactant | Methyl 3-mercapto-D-valinate hydrochloride | HCID 12278508 | — |
| Product | N-[N-[(1,1-dimethylethoxy)carbonyl]-N-methyl-L-phenylalanyl]-3-mercapto-D-valine, methyl ester | HCID 131717963 | — |
Reaction Steps
The title compound was synthesized by coupling Nα -Boc-(N-methyl) phenylalanine (19.0 g, 68.0 mmol) to 13.8 g (69.0 mmol) of D-penicillamine methylester hydrochloride using the procedure described above in Example 19. The title compound was obtained as a white solid (29.6 g, 99.3%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05216124 |
| Source dataset | uspto-grants-1993_06 |
| ORD ID | ord-44e0de502cb64c53ab633e36161e2ce3 |
| Source note | uspto-grants-1993_06 |