Water → 2,6-Diamino-7-tert-butoxy-7-oxoheptanoic acid

Participants

Reaction Conditions

Reaction Steps

A pH electrode was put in a solution of 14.6 g of lysine dissolved in 100 ml of water, and 55 g (1.5 mol equivalent against lysine) of 4-tert-butyloxycarbonyloxyphenyldimethylsulfonium methylsulfate was added thereto while stirring at 20° C. The reaction was carried out at pH 8.0 according to the method of Working Example 10 to afford 17.7 g (72% of the theoretical value) of the desired product.

Provenance & Evidence