Chloroform → HCID 14975208, compound

HRID 1586924Notes

Reaction equation

HRID 1586924 reaction equation
[OH:1][C:2]1[C:3]([C:9]2[C:14]([OH:15])=[CH:13][CH:12]=[C:11]([CH3:16])[N:10]=2)=[N:4][C:5]([CH3:8])=[CH:6][CH:7]=1.[C:17](Cl)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1.C(Cl)(Cl)Cl>N1C=CC=CC=1>[C:17]([O:15][C:14]1[C:9]([C:3]2[C:2]([O:1][C:17](=[O:24])[C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=3)=[CH:7][CH:6]=[C:5]([CH3:8])[N:4]=2)=[N:10][C:11]([CH3:16])=[CH:12][CH:13]=1)(=[O:24])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

5

Reactant 3

HCID 6212ChloroformHCID 7412Benzoyl chlorideHCID 135492986HCID 135492986, compound

Product 1

HCID 14975208HCID 14975208, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3,3'-Dihydroxy-6,6'-dimethyl-2,2'-bipyridine (5) (0.22 g, 1.02 mmoles) was dissolved in 12 ml pyridine and benzoylchloride (0.30 g, 2.13 mmoles) was added. After stirring for 1.5 hours at room temperature, 100 ml chloroform was added and the solution was extracted with 100 ml saturated sodium hydrogen carbonate solution. The chloroform phase was dried and evaporated to dryness. The product was crystallized as a grey powder from cyclohexane.

Workup

  1. extractionthe solution was extracted with 100 ml saturated sodium hydrogen carbonate solution
  2. dry with materialThe chloroform phase was dried
  3. customevaporated to dryness
  4. customThe product was crystallized as a grey powder from cyclohexane

Sources & evidence

ORD record
ord-c0322854a3d64aca8b6717028fef52e0
Source dataset
uspto-grants-1993_06
Patent number
US05216134

Reaction notes

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