反应详情

6,6'-Dimethyl-4-nitro-2,2'-bipyridine-N-oxide (0.50 g, 2.0 mmoles) was dissolved in acetyl bromide (10.0 ml) and phosphorus tribromide (2.5 ml). After refluxing for 1.5 hours the mixture was poured into 100 g ice and the solution was neutralized with 30% sodium hydroxide solution. The mixture was extracted with chloroform, the chloroform phase was dried and evaporated. The product was purified by means of flash chromatography.

1. temperatureAfter refluxing for 1.5 hours the mixture
2. extractionThe mixture was extracted with chloroform
3. dry with materialthe chloroform phase was dried
4. customevaporated
5. customThe product was purified by means of flash chromatography