HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1586931Generated: November 1, 2026
Ethylene Glycol → 4-(2-hydroxyethoxy)-6,6'-dimethyl-2,2'-bipyridine-N-oxide
https://huagongshe.com/reaction/1586931
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethylene Glycol | HCID 174 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 6,6'-Dimethyl-4-nitro-2,2'-bipyridine-N-oxide | HCID 11032132 | — |
| Product | 4-(2-hydroxyethoxy)-6,6'-dimethyl-2,2'-bipyridine-N-oxide | HCID 19760122 | — |
Reaction Steps
Sodium hydride (2.07 g, 51.8 mmoles) was added to 1,2-dihydroxyethane (100 ml). After 15 minutes 6,6'-dimethyl-4-nitro-2,2'-bipyridine-N-oxide (17) (6.35 g, 25.9 mmoles) was added and the mixture was stirred at 60° C. for 4 hours. Excess of 1,2-dihydroxyethane was removed by evaporation in high vacuum and the product was purified by flash chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05216134 |
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| Source dataset | uspto-grants-1993_06 |
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| ORD ID | ord-b8e02c553ef247bea26a3a872067728a |
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| Source note | uspto-grants-1993_06 |
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