HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 4-Fluorobenzoic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| Reactant | 5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-amine | HCID 11469760 | — |
| Product | 4-Fluorobenzoic Acid | HCID 9973 | — |
Reaction Steps
In a manner analogous to Example 9, by reacting 5.9 g of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylamine with 4-fluorobenzoyl chloride, obtained from 4 g of 4-fluorobenzoic acid and 15 ml of thionyl chloride, there were obtained, after recrystallization from hexane/ethyl acetate, 6.3 g of p-fluoro-N-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)benzamide, m.p. 160°-162° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05216153 |
| Source dataset | uspto-grants-1993_06 |
| ORD ID | ord-25e649faaca74f4b8dd06b9bf315e853 |
| Source note | uspto-grants-1993_06 |