Sulfuric Acid → HCID 15229552, compound

Participants

Reaction Steps

A mixture of 2'-Phenyl-6',7',8',9'-tetrahydro-spiro[(1,3)dioxolane2,8'(5H)-indolo[3,2-d]-pyrimidine] (200 mg), 3N sulfuric acid (1.5 mL) and methanol (1.5 mL) was kept at room temperature for 2 days. The reaction mixture was neutralized with 2N ammonium hydroxide and the product was extracted with methylene chloride. After drying over magnesium sulfate, the solvent was remov ed in vacuo and the residue was crystallized froom ether/hexane to afford 2-Phenyl-5,6,7,9-tetrahydro-8H-indolo[3,2-d]pyrimidin-8-one (Compound 30) melting at 246°-247° C.

Provenance & Evidence