Dimethyl Sulfoxide → HCID 19760329, compound

Participants

Reaction Steps

A mixture of 3.0 g (7.28 mmol) of the compound of step A, above, 4.74 g (14.6 mmol) of Cs2CO3, 1.62 g (14.6 mmol) of trimethylamine N-oxide and 24 ml of dimethyl sulfoxide is stirred at 120° C. for 4 days. The reaction mixture is cooled and diluted with 400 ml of water producing a brown precipitate which is collected by filtration. The crude product is dissolved in methanol, filtered and evaporated onto silica gel. The coated silica gel is then added to a column and eluted with 10% methanol in chloroform to yield 0.75 g (24%) of title compound as an off white solid.

Provenance & Evidence