HCID 19760396, compound → HCID 19760395, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 13 mg (0.026 mmol) of 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl-1-(3-phenylpropyl) -3-cyano-5-hydroxymethylpyridine in 0.45 ml of dichloroethane was added 5 mg of activated manganese dioxide. The mixture was heated at 80° C. for one hour. Then the mixture was filtered and concentrated. The resulting residue was purified by thin layer chromatography (AcOEt:Hexane 1:1) to give 7.4 mg (0.015 mmol) of 1,4-dihydro-4-(3,4-dimethoxyphenyl)-2,6-dimethyl -1-(3-phenylpropyl)-3-cyano-5-formylpyridine (yield: 58%).

Provenance & Evidence