Cholic Acid → HCID 18652176, compound

Participants

Reaction Steps

Cholic acid is treated with zinc chloride to afford the corresponding chol-8(14)en-24-oic acid which is subsequently reduced by treatment with lithium aluminum hydride to the corresponding alcohol. Treatment of the alcohol with p-toluenesulfonyl chloride in the presence of 4-dimethylaminopyridine and triethylamine gives the tosylate which is then converted to the 4-chlorophenylseleno derivative by treatment with bis(4-chlorophenyl)diselenide in the presence of sodium borohydride.

Provenance & Evidence