Pyridine → HCID 86746915, compound

Participants

Reaction Steps

A mixture of 3α, 12α-dihydroxy-17β-[(1,1-diphenyl)-1-penten-4-yl]-5β-androstane (15.6 g), pyridine (14.8 ml), acetic anhydride (57.4 ml), 4-dimethylaminopyridine (3.71 g) and toluene (60 ml) is stirred at room temperature for about 30 minutes, diluted with ether and water and the layers are separated. The organic solution is washed water, dried over magnesium sulfate, filtered and concentrated in vacuo. The crude product is crystallized from 25% ether in hexane to give the desired product as an off-white solid.

Provenance & Evidence