Benzoyl Peroxide → HCID 86746917, compound

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Reaction Steps

A mixture of 3α, 12α-diacetoxy-17β-[(1,1-diphenyl)-1-penten-4-yl]-5β-androstane (7.24 g), N-bromosuccinimide (2.26 g) and benzoyl peroxide (0.256 g) in anhydrous carbon tetrachloride (250 ml) is stirred at reflux, while being illuminated with a 275-watt sun lamp, for about 45 minutes. The mixture is cooled, filtered, and concentrated in vacuo. The resulting oil is dissolved in anhydrous pyridine (12.2 ml), the solution refluxed for about 1 hour, and concentrated in vacuo. The residue is dissolved in ether, filtered, and the ether solution washed with dilute sodium chloride solution, dried over magnesium sulfate, filtered and concentrated in vacuo. The crude product is used, without further treatment, for the next step.

Provenance & Evidence