Methanol → HCID 22295513, compound

Participants

Reaction Steps

A mixture of 3α, 12α-diacetoxy-5β-androstan-17-one (5.5 g) and lithium hydroxide monohydrate (1.7 g) in a solution of methanol (20 ml), tetrahydrofuran (20 ml) and water (20 ml) is stirred at room temperature for about two hours, diluted with ethyl acetate and washed three times with water. The organic solution is dried over magnesium sulfate, filtered and concentrated in vacuo. Benzene is azeotroped from the residue to give the desired product which is used, without further treatment, for the next step.

Provenance & Evidence