Imidazole → HCID 18652195, compound

Participants

Reaction Steps

To a mixture of 3α, 12α-dihydroxy-17β-[(1,1-diphenyl)-1-penten-4-yl]-5β-androstane (10.2 g), imidazole (1.64 g) and 4-dimethylaminopyridine (0.256 g) in dimethylformamide (30 ml) is added tert-butylchlorodiphenylsilane (6.04 g) and the mixture stirred for about 3.5 hours and diluted with ether/hexane (1:1). The solution is washed with saturated sodium bicarbonate, dried over magnesium sulfate, filtered and concentrated in vacuo. The crude product is purified by flash chromatography in 50% ether in hexane to give the desired product.

Provenance & Evidence