Apocholic acid → HCID 67857083, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of lithium aluminum hydride (6.7 g) in tetrahydrofuran (50 ml) is cooled to 0° C. and a solution of 3α, 12α-dihydroxy-5β-chol-8(14)-en-24-oic acid (15.3 g) in tetrahydrofuran (350 ml) is added to dropwise. The mixture is warmed to room temperature, stirred for about 17 hours, and quenched by dropwise addition of water (6.7 ml), 15% sodium hydroxide solution (6.7 ml), and water (6.7 ml). The mixture is filtered, washing the alumina salts with 20% ethanol in ethyl acetate, and the filtrate concentrated in vacuo to give the desired product which is used, without further treatment, for the next step.

Provenance & Evidence