HCID 70219528, compound → HCID 13747407, compound

HRID 1587082Notes

Reaction equation

HRID 1587082 reaction equation
[CH2:1]([O:3][C:4]1[CH:16]=[C:15]([CH2:17][C:18]([NH:20][CH:21]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[N:31]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)[CH2:22][CH2:23][CH3:24])=[O:19])[CH:14]=[CH:13][C:5]=1[CH:6]=[CH:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH3:2].[H][H]>C(O)C.[Pd]>[CH2:1]([O:3][C:4]1[CH:16]=[C:15]([CH2:17][C:18]([NH:20][CH:21]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[N:31]2[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]2)[CH2:22][CH2:23][CH3:24])=[O:19])[CH:14]=[CH:13][C:5]=1[CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[CH3:2]

Participants

5

Reactant 2

HCID 70219528HCID 70219528, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13747407HCID 13747407, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of ethyl 2-ethoxy-4-[N-(1-(2-piperidinophenyl)-1-butyl)-aminocarbonylmethyl]-cinnamate (0.54 g, 1.1 mmol) in ethanol (15 ml) is hydrogenated for 1 hour at ambient temperature and under 3 bars of hydrogen on 10% palladium/charcoal (0.1 g). The mixture is filtered, concentrated by evaporation in vacuo and the evaporation residue is crystallized from petroleum ether.

Workup

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated by evaporation in vacuo
  3. customthe evaporation residue is crystallized from petroleum ether

Sources & evidence

ORD record
ord-9204eaaa7ef84f6095d70ecfaab6a1ed
Source dataset
uspto-grants-1993_06
Patent number
US05216167

Reaction notes

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