Trimethylamine → HCID 86746909, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 0.7 g of cholest-5-en-3β-yl (S)-2-[[(2-bromoethoxy)hydroxyphosphinyl]oxy]propionate in 15 ml of toluene is treated with 15 ml of trimethylamine in a dry-ice bath. The mixture is heated to 60° C. for 30 hours. After cooling the reaction mixture is taken up in toluene and concentrated. The residue is taken up in 30 ml of methanol, treated with 2 g of silver carbonate and stirred at 50° C. for 0.5 hour. The precipitate is filtered off, concentrated and there is obtained 0.6 g of O-[[(S)-1-[(cholest-5-en-3β-yloxy)carbonyl]ethoxy]hydroxyphosphinyl]choline hydroxide internal salt, MS: 624 (M+H+).

Provenance & Evidence