HuagongsheHuagongshe Chemistry Print Report · For research reference only
(+/-)-cis-1-Methylethyl 6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane4-acetate → Atorvastatin Impurity 206
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (+/-)-cis-1-Methylethyl 6-(cyanomethyl)-2,2-dimethyl-1,3-dioxane4-acetate | HCID 10999646 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Atorvastatin Impurity 206 | HCID 11139823 | — |
Reaction Steps
A mixture of (±)-cis-1-methylethyl 6-(cyanomethyl)2,2-dimethyl-1,3-dioxane-4-acetate, 0.55 g, in glacial acetic acid is hydrogenated with platinum dioxide at 50 pounds per square inch (PSI). Concentration, dilution with ethyl acetate and bicarbonate wash, followed by washing with brine and drying provides 250 mg of (±)-cis-1-methylethyl 6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate. MS 260.1, 244.1
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05216174 |
| Source dataset | uspto-grants-1993_06 |
| ORD ID | ord-8d3f71ce60ea4638ac634c9305b309b9 |
| Source note | uspto-grants-1993_06 |