Methyl iodide → N-{2-(4-Hydroxypiperidino)-1-[p-(5-isoquinolinesulfonyloxy)benzyl]ethyl)-N-methyl-5-isoquinolinesulfonamide

HRID 1587189Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1587189
C([O:4][CH:5]1[CH2:10][CH2:9][N:8]([CH2:11][CH:12]([NH:34][S:35]([C:38]2[C:39]3[CH:40]=[CH:41][N:42]=[CH:43][C:44]=3[CH:45]=[CH:46][CH:47]=2)(=[O:37])=[O:36])[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][S:21]([C:24]3[C:25]4[CH:26]=[CH:27][N:28]=[CH:29][C:30]=4[CH:31]=[CH:32][CH:33]=3)(=[O:23])=[O:22])=[CH:16][CH:15]=2)[CH2:7][CH2:6]1)(=O)C.[CH3:48]I>>[OH:4][CH:5]1[CH2:6][CH2:7][N:8]([CH2:11][CH:12]([N:34]([CH3:48])[S:35]([C:38]2[C:39]3[CH:40]=[CH:41][N:42]=[CH:43][C:44]=3[CH:45]=[CH:46][CH:47]=2)(=[O:37])=[O:36])[CH2:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][S:21]([C:24]3[C:25]4[CH:26]=[CH:27][N:28]=[CH:29][C:30]=4[CH:31]=[CH:32][CH:33]=3)(=[O:22])=[O:23])=[CH:16][CH:15]=2)[CH2:9][CH2:10]1

Komponenten

3

Edukt 2

HCID 6328Methyl iodideHCID 131717151N-{2-[4-acetoxypiperidino]-1-[p-(5-isoquinolinesulfonyloxy)benyl]ethyl}-5-isoquinolinesulfonamide

Produkt 1

HCID 19796382N-{2-(4-Hydroxypiperidino)-1-[p-(5-isoquinolinesulfonyloxy)benzyl]ethyl)-N-methyl-5-isoquinolinesulfonamide

Versuchsvorschrift

The amorphous compound obtained in Example 103 was treated with methyl iodide according to the procedure in Example 89 and the intermediate product was subjected to alkaline hydrolysis according to the procedure in Example 104, to obtain the same product as in Example 99.

Aufarbeitung

  1. customthe intermediate product was subjected to alkaline hydrolysis
  2. customto obtain the same product as in Example 99

Quellen und Nachweise

ORD-Eintrag
ord-0bca97668f3649b193cdfe88f26723d6
Quelldatensatz
uspto-grants-1993_06
Patentnummer
US05216150

Notizen zur Reaktion

Wird geladen…