HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1587261Generated: October 30, 2026
Tributyltin Chloride → HCID 131717967, compound
https://huagongshe.com/reaction/1587261
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Tributyltin Chloride | HCID 15096 | — |
| Reactant | (S)-2-(((Benzyloxy)carbonyl)amino)-3-(4-chlorophenyl)propanoic acid | HCID 3033106 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 131717967 | HCID 131717967 | — |
Reaction Steps
To a solution of N-CBZ p-chloro phenylalanine 1 (one equivalent) in anhydrous THF at 100° C. is added n-butyllithium (3.3 equiv.). After one hour, a solution of Bu3SnCl (excess) is added. Other tri-alkyl-Sn compounds may be used in place of Bu3SnCl. The solution is warmed to 0° C. and quenched by the addition of saturated NH4Cl. Extractive work-up into diethyl ether affords the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05217705 |
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| Source dataset | uspto-grants-1993_06 |
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| ORD ID | ord-8d6a0ff5d8ad44bbb35fe707a80aa4e4 |
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| Source note | uspto-grants-1993_06 |
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