Dicyclohexylcarbodiimide → HCID 19757567, compound

Participants

Reaction Steps

15 ml of dichloromethane was added to 0.38 g (1.58 mM) of 5-octylthiophene-2-carboxylic acid and 0.42 g (1.58 mM) of 4-[3-(butyldimethylsilyl)propoxy]phenol, followed by stirring at room temperature to the mixture, 0.31 g (1.50 mM) of N,N'-dicyclohexylcarbodiimide (DCC) and 0.02 g of 4-pyrrolidinopyridine were added, followed by stirring for 5 hours at room temperature. The resultant dicyclohexylurea was recovered by filtration, followed by washing with dichloromethane to be added to the filtrate. The resultant dichloromethane solution was condensed into a solid under reduced pressure, followed by purification by silica gel column chromatography (eluent: toluene) and recrystallization from ethanol to obtain 0.45 g of 4-[3-(butyldimethylsilyl)propoxy]phenyl 5-octylthiophene-2-carboxylate (Yield: 61.4 %). ##STR71##

Provenance & Evidence