Phenol → HCID 14745383, compound

HRID 1587272Notes

Reaction equation

HRID 1587272 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:8][C:9]([Cl:16])([Cl:15])[C:10]([N:12]=[C:13]=[O:14])=[O:11]>O.CC(C)=O>[Cl:8][C:9]([Cl:16])([Cl:15])[C:10]([NH:12][C:13](=[O:14])[O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:11]

Participants

5

Reactant 2

HCID 996PhenolHCID 76400Trichloroacetyl isocyanate

Product 1

HCID 14745383HCID 14745383, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

4.7 g (0.05 mol) of phenol are dissolved in a mixture of 10 g of water and 10 g of acetone. 9.4 g (0.05 mol) of trichloroacetyl isocyanate are subsequently added dropwise over the course of 30 minutes. The mixture is stirred at room temperature for 30 minutes and under reflux for 2.5 hours. The solvent mixture is evaporated in a rotary evaporator, and the solid obtained is recrystallized from DMSO (dimethyl sulfoxide).

Workup

  1. temperatureunder reflux for 2.5 hours
  2. customThe solvent mixture is evaporated in a rotary evaporator
  3. customthe solid obtained
  4. customis recrystallized from DMSO (dimethyl sulfoxide)

Sources & evidence

ORD record
ord-5a2ed96e20f94abdb6a57f9277891cac
Source dataset
uspto-grants-1993_06
Patent number
US05217843

Reaction notes

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