HCID 19757659, compound → HCID 178516225, compound

HRID 1587282Notes

Reaction equation

HRID 1587282 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].ClC1N=CN=C2C=1NC=N2.[C@@H:17]1([N:26]2[C:35]3[N:34]=[CH:33][N:32]=[C:30]([OH:31])[C:29]=3[N:28]=[CH:27]2)[O:25][C@H:22]([CH2:23][OH:24])[C@@H:20]([OH:21])[C@H:18]1[OH:19].N1CCCC1=O.N1C(=O)C2NC=NC=2N=C1N>>[NH:1]1[CH2:5][CH2:4][CH2:3][C:2]1=[O:6].[C@@H:17]1([N:26]2[C:35]3[N:34]=[CH:33][N:32]=[C:30]([OH:31])[C:29]=3[N:28]=[CH:27]2)[O:25][C@H:22]([CH2:23][OH:24])[C@@H:20]([OH:21])[C@H:18]1[OH:19]

Participants

4

Reactant 3

HCID 19757659HCID 19757659, compoundHCID 136331473HCID 136331473, compoundHCID 178521066(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-hydroxypurin-9-yl)oxolane-3,4-diol

Product 1

HCID 178516225HCID 178516225, compound

Procedure

6-Chloropurine pyrrolidone (1 mmol) was converted to the inosine derivative by the method used for the preparation of the guanine pyrrolidone derivative. The compound is purified by chromatography on silica using a gradient of methanol (5-25%) in chloroform.

Workup

  1. customThe compound is purified by chromatography on silica using a gradient of methanol (5-25%) in chloroform

Sources & evidence

ORD record
ord-af7c54225fb54cb9a51fdbc546cec085
Source dataset
uspto-grants-1993_06
Patent number
US05217866

Reaction notes

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