Ammonia → HCID 15663632, compound

Participants

Reaction Steps

A solution of 4-(1-m-nitrobenzoyl-1,2,3-triazol-4-yl)-1-azabicyclo[2.2.1]heptane (D25) (1 g, 0.0032 mole) in methanol (50 ml) was saturated with ammonia gas. The solution allowed to stand at room temperature for 3 days and then concentrated in vacuo to a gum. The gum was chromatographed on alumina in a gradient of 10-20% methanol in chloroform, elution with 15% methanol in chloroform produced a gum which crystallised from ethyl acetate to afford the title compound (D26, 450mg, 0.0027 mole, 85%).

Provenance & Evidence