HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoyl Peroxide → Ethyl 5-(bromomethyl)oxazole-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoyl Peroxide | HCID 7187 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | Ethyl 5-methyl-1,3-oxazole-2-carboxylate | HCID 22099282 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | Ethyl 5-(bromomethyl)oxazole-2-carboxylate | HCID 19105062 | 100% |
Reaction Steps
To a mixture of 6.2 parts of ethyl 5-methyl-2-oxazolecarboxylate and 191 parts of dry tetrachloromethane there were added 7.1 parts of N-bromosuccinimide and a few parts of benzoylperoxide under a nitrogen atmosphere. The whole was stirred for 1 hour at reflux temperature. After cooling, the reaction mixture was filtered and the filtrate was evaporated, yielding 11 parts (100%) of ethyl 5-(bromomethyl)-2-oxazolecarboxylate (interm. 21).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05217980 |
| Source dataset | uspto-grants-1993_06 |
| ORD ID | ord-01b0869db2564a3ea8578191da818659 |
| Source note | uspto-grants-1993_06 |