反应详情

A mixture of 1,2-bis(4-methoxyphenyl)-2-chloroethanone (5.00 g) and ethyl 2-amino-2-thioxoacetate (3.44 g) in ethanol (30 ml) was refluxed for 4 hours. After allowing to cool to ambient temperature, the reaction mixture was filtered and washed with ethanol, and the filtrate was evaporated in vacuo. The residue was subjected to column chromatography on silica gel (300 g) and eluted with a mixture of hexane and ethyl acetate (8:1, V/V). The fractions containing the object compound were combined and concentrated under reduced pressure, and to give a oily compound of 4,5-bis(4-methoxyphenyl)-2-ethoxycarbonylthiazole (6.10 g).

1. temperaturewas refluxed for 4 hours
2. filtrationthe reaction mixture was filtered
3. washwashed with ethanol
4. customthe filtrate was evaporated in vacuo
5. washeluted with a mixture of hexane and ethyl acetate (8:1, V/V)
6. additionThe fractions containing the object compound
7. concentrationconcentrated under reduced pressure