Methyl isothiocyanate → HCID 9977391, compound

Participants

Reaction Steps

A suspension of 2-amino-4,5-bis(4-methoxyphenyl)thiazole hydrochloride (1.00 g) in N,N-dimethylformamide (5 ml) was added dropwise to a suspension of sodium hydride (60% dispersion in mineral oil) (0.13 g) in N,N-dimethylformamide (5 ml) at 0° C. for 30 minutes. The reaction mixture was stirred at room temperature for 30 minutes. After methyl isothiocyanate (2.19 ml) was added dropwise to the reaction mixture, the reaction mixture was stirred at 80° C. for 5.5 hours. After allowing to cool to room temperature, the resulting precipitates were collected by filtration, washed with diisopropyl ether and diethyl ether to give 4,5-bis(4-methoxyphenyl)2-(3-methylthioureido)thiazole (0.81 g).

Provenance & Evidence