反应详情

A mixture of 1,2-bis(4-methoxyphenyl)-2-chloroethanone (1.00 g) and N-diaminomethylenethiourea (0.65 g) in ethanol (20 ml) was refluxed for 12 hours. After allowing to cool to ambient temperature, then the reaction mixture was poured into water and extracted with ethyl acetate. The separated organic layer was washed with water and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was chromatographed n alumina, eluting with a mixture of chloroform and methanol. The desired fractions were combined and concentrated in vacuo. The residue was washed with isopropy ether to give 4,5-bis(4methoxyphenyl)-2-guanidinothiazole (0.65 g).

1. temperaturewas refluxed for 12 hours
2. extractionextracted with ethyl acetate
3. washThe separated organic layer was washed with water and brine
4. dry with materialdried over magnesium sulfate
5. customevaporated in vacuo
6. customThe residue was chromatographed n alumina
7. washeluting with a mixture of chloroform and methanol
8. concentrationconcentrated in vacuo
9. washThe residue was washed with isopropy ether