HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroacetyl chloride → 2-(2-Chloroacetamido)-3-methylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroacetyl chloride | HCID 6577 | — |
| Reactant | 2-Amino-3-methylbenzoic acid | HCID 78101 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2-(2-Chloroacetamido)-3-methylbenzoic acid | HCID 10775690 | 79% |
Reaction Steps
3-Methylanthranilic acid 10 g (0.07 mol) was dissolved in dried benzene 100 ml. To this solution, chloroacetylchloride 5.81 ml (0.07 mol) was added dropwise at room temperature and heated under reflux for two hours. After cooling, deposited crystals were collected by filtration and recrystallized from benzene-toluene to obtain 3-methyl-N(chloroacetyl)anthranilic acid 11.7 g (yield: 79%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05217961 |
| Source dataset | uspto-grants-1993_06 |
| ORD ID | ord-2fd3153c55fa4a25989a38048270e672 |
| Source note | uspto-grants-1993_06 |