Potassium Bicarbonate → HCID 67858853, compound

HRID 1587417Notes

Reaction equation

HRID 1587417 reaction equation
C(=O)([O-])O.[K+].[CH3:6][C:7]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:8]=1[CH2:9][C:10]1[C:11]([C:17]3[C:18](=[O:24])[CH2:19][CH:20]=[CH:21][C:22]=3[N:23]=1)=[N:12]2>>[CH3:6][C:7]1[CH:8]=[C:13]2[C:14]([CH2:9][C:10]3[C:11]([C:17]4[C:18](=[O:24])[CH2:19][CH:20]=[CH:21][C:22]=4[N:23]=3)=[N:12]2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 516893Potassium BicarbonateHCID 67858820HCID 67858820, compound

Product 1

HCID 67858853HCID 67858853, compoundYield 83%

Conditions

Temperature
120 °C

Procedure

The resulting compound 5.0 g (0.02 mmol) was mixed with polyphosphoric acid 176 g and heated at 120° C. for 2 hours. After heating, the reaction mixture was poured into ice water. The resulting solution was neutralized with an aqueous solution saturated with potassium hydrogencarbonate and deposited crystals were collected by filtration to obtain a mixture of 1-methyl-6,11-dihydroindolo[3,2-b]-quinoline-6-one and 3-methyl-6,11-dihydroindolo[3,2-b]-quinoline-6-one (4.1 g (yield: 83%)).

Workup

  1. temperatureAfter heating
  2. filtrationwere collected by filtration
  3. customto obtain

Sources & evidence

ORD record
ord-91ad07a37cc345daafc51cc7b9025c18
Source dataset
uspto-grants-1993_06
Patent number
US05217961

Reaction notes

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