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Sodium Sulfate → 1-Dodecylazepane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Sulfate | HCID 24436 | — |
| 反応物 | Laurocapram | HCID 42981 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | 1-Dodecylazepane | HCID 3366129 | 93.5% |
反応手順
56.2g (0.2 mol) of 1-dodecylazacycloheptan-2-one in 100ml diethyl ether was added dropwise to a suspension of 7.6g (0.2 mol) lithium aluminum hydride in 100ml diethyl ether under argon at room temperature. After 5 hours of stirring, 20ml saturated sodium sulfate was added dropwise. The mixture was filtered and the filtrate was dried with magnesium sulfate, filtered and concentrated. The resulting oil was distilled (130°/.03 mm) to yield 50.03g (93.5%) of 1-n-dodecylazacycloheptane.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05218113 |
| 出典データセット | uspto-grants-1993_06 |
| ORD ID | ord-124f3113283747acbf5f492760bd94d0 |
| 出典メモ | uspto-grants-1993_06 |