Hydrochloric Acid → HCID 178435372, compound

Participants

Reaction Steps

Concentrated hydrochloric acid (0.5 ml) was added to a solution of 5,7-diethyl-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,6-naphthyridin-2(1H)-one (500 mg) (A) in methanol (5 ml) and the mixture was stirred for 30 minutes. Volatile material was removed by evaporation and the residue was dissolved in hot ethanol. The solution was cooled, evaporated to small volume and the product collected by filtration to give 5,7-diethyl-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-1,6-naphthyridin-2(1H)-one hydrochloride (230 mg), as a solid, m.p. 265°-269° C. (decomposition); NMR (d6 -DMSO): 1.15-1.4(m,6H), 2.95(q,2H), 3.35(q,2H), 5.55(s,2H), 6.9(d,1H), 7.05(d,2H), 7.2(d,2H), 7.4-7.75(m,5H), 8.45(d,1H); mass spectrum (+ve FAB, methanol/NBA): 459(M+Na)+, 437(M+H)+ ; microanalysis, found: C, 64,8; H, 5.4; N, 17.4; C26H24N6O.HCl.0.5H2O requires C, 64.8; H, 5.4; N, 17.4%.

Provenance & Evidence