Ammonia → HCID 19757876, compound

Participants

Reaction Steps

Mix 1,19-bis[(phenyl)methyl]-1,19-bis[(4-methylphenyl)sulfonyl]-6,14-bis(benzoyl)-1,6,14,19-tetraazanonadecane (4g, 4 mmol) in dry liquid ammonium (25 mL) at -40° C. Add small pieces of sodium until a permanent blue color remains. Discharge the excess sodium with saturated ammonium chloride. Allow the ammonia to evaporate spontaneously and partition the residue between ethyl acetate and water. Separate the organic phase, dry (MgSO4) and evaporate the solvent on vacuo. Purify by silica gel chromatography to give the title compound.

Provenance & Evidence