HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium p-toluenesulfinate → 20-Methyl-1alpha,3beta-bis(methoxymethoxy)-21-p-tolylsulfonylpregna-5,7-diene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium p-toluenesulfinate | HCID 2723791 | — |
| Reactant | Benzenesulfinic acid, sodium salt | HCID 2723840 | — |
| Reactant | 21-Bromo-20-methyl-1alpha,3beta-bis(methoxymethoxy)pregna-5,7-diene | HCID 67788422 | — |
| Reactant | 21-Bromo-20-methyl-1alpha,3beta-bis(methoxycarbonyloxy)pregna-5,7-diene | HCID 67788537 | — |
| Product | 20-Methyl-1alpha,3beta-bis(methoxymethoxy)-21-p-tolylsulfonylpregna-5,7-diene | HCID 67788113 | 63.3% |
Reaction Steps
The procedure of Example 5 was repeated except that 59 mg of 21-bromo-20-methyl-1α,3β-bis(methoxymethoxy)pregna-5,7-diene and 95 mg of sodium p-toluenesulfinate were used in lieu of 65 mg of 21-bromo-20-methyl-1α,3β-bis(methoxycarbonyloxy) pregna-5,7-diene and 80 mg of sodium benzenesulfinate, respectively, to give 43 mg of 20-methyl-1α,3β-bis(methoxymethoxy)-21-p-tolylsulfonylpregna-5,7-diene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05218109 |
| Source dataset | uspto-grants-1993_06 |
| ORD ID | ord-6acfa0996b3b49678a4c8240d84bc310 |
| Source note | uspto-grants-1993_06 |