HuagongsheHuagongshe Chemistry Print Report · For research reference only
1alpha,3beta-Bis(methoxycarbonyloxy)pregna-5,7-diene-20-carboxylic acid → Methyl 1alpha,3beta-bis(t-butyldimethylsilyloxy)pregna-5,7-diene-20-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1alpha,3beta-Bis(methoxycarbonyloxy)pregna-5,7-diene-20-carboxylic acid | HCID 53764217 | — |
| Reactant | 1alpha,3beta-Bis(t-butyldimethylsilyloxy)pregna-5,7-diene-20-carboxylic acid | HCID 54107153 | — |
| Product | Methyl 1alpha,3beta-bis(t-butyldimethylsilyloxy)pregna-5,7-diene-20-carboxylate | HCID 54522709 | 84.6% |
Reaction Steps
The procedure of Example 7 was repeated except that 112 mg of 1α,3β-bis(t-butyldimethylsilyloxy)pregna-5,7-diene-20-carboxylic acid obtained in Example 23 was used in lieu of 85 mg of 1α,3β-bis(methoxycarbonyloxy)pregna-5,7-diene-20-carboxylic acid to give 91 mg of methyl 1α,3β-bis(t-butyldimethylsilyloxy)pregna-5,7-diene-20-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05218109 |
| Source dataset | uspto-grants-1993_06 |
| ORD ID | ord-7de9117226e74704b83a2c8f1df1eac6 |
| Source note | uspto-grants-1993_06 |