反应详情

6 g of diethyl 2-(3-cyanopropyl)malonate are added dropwise, at -10° C., to a suspension of 3 g of LiAlH4 in 100 ml of dry diethyl ether under N2. The mixture is slowly warmed to room temperature and then refluxed for 3 h. After renewed cooling to -10° C., the excess hydride is decomposed with water. The precipitate is removed on a frit and washed several times with diethyl ether. The ether solution is dried over MgSO4, filtered and evaporated in a rotary evaporator. Yield 0.66 g of 2-(4-aminobutyl)-1,3-propanediol, detectable in the 1H NMR and by C and H analysis. Glassy solid, melting point 126° C. (honey-like above 60° C.).

1. temperaturerefluxed for 3 h
2. temperatureAfter renewed cooling to -10° C.
3. customThe precipitate is removed on a frit
4. washwashed several times with diethyl ether
5. dry with materialThe ether solution is dried over MgSO4
6. filtrationfiltered
7. customevaporated in a rotary evaporator
8. customGlassy solid, melting point 126° C. (honey-like above 60° C.)