Butyl iodide → 1'-Butylspiro[indene-1,4'-piperidine]

Participants

Reaction Steps

In the same way as that described in Example 1, step 5, the title compound was prepared, using spiro[1H-indene-1,4'-piperidine] (333 mg, 1.8 mmol), DMF (15 ml), potassium carbonate (0.26 g, 1.9 mmol) and iodobutane (267 μl, 2.4 mmol). The crude residue was chromatographed in dichloromethane:methanol 95:5, to give 1'-butylspiro[1H-indene-1,4'-piperidine] (136 mg, 31%) as a clear oil.

Provenance & Evidence