反应详情

To a solution of 4.89 g (21.9 mmol) of 2-acetoxymethyl-6-butoxypyridine dissolved in 20 ml of ethanol was added 20 ml of an 8% sodium hydroxide solution, and the mixture was refluxed for one hour. After removal of the ethanol under a reduced pressure, the residue was extracted with ether and separated by silica gel chromatography (ethyl acetate:hexane=1:3) to obtain 4.29 g of the desired product (yield 100%).

1. temperaturethe mixture was refluxed for one hour
2. customAfter removal of the ethanol under a reduced pressure
3. extractionthe residue was extracted with ether
4. customseparated by silica gel chromatography (ethyl acetate:hexane=1:3)