1-Bromohexane → HCID 19756143, compound

Participants

Reaction Steps

To a solution of 12.0 g (0.11 mol) of 6-hydroxy-2-methylpyridine (commercially available) and 18.2 g (0.11 mol) of n-hexyl bromide dissolved in 100 ml of N,N-diethylformamide was added 15.2 g (0.11 mol) of potassium carbonate, and the mixture was stirred at 80° to 90° C. for 8 hours. Into the resultant mixture was poured 300 ml of ice-water, the mixture was extracted with ethyl acetate, and the oily extract obtained was separated by silica gel column chromatography (ethyl acetate:hexane=1:9) to give 12.1 g of an oily substance (yield 57.0%).

Provenance & Evidence