Acetic Anhydride → HCID 19756108, compound

Participants

Reaction Conditions

Reaction Steps

An amount 40 ml of acetic anhydride was stirred at about 115° C. and a solution of 5.50 g of 6-hexyloxy-α-picoline N-oxide in 20 ml of glacial acetic acid was dropwise added over about one hour. After the dropwise addition, the mixture was stirred at 130° C. for 5 hours, acetic acid and acetic anhydride were removed by concentration under a reduced pressure, the reaction mixture was dissolved in ether, and the remaining acetic acid was neutralized with a sodium hydrogen carbonate solution. After extraction with ether and concentration under a reduced pressure, the residue was separated by silica gel column chromatography (ethyl acetate:hexane=1:9) to give 6.85 g of the desired product (yield 100%).

Provenance & Evidence