Sodium Hydroxide → HCID 19756139, compound

Participants

Reaction Steps

To a solution of 6.85 g (27 mmol) of 2-acetoxymethyl-6-hexyloxypyridine dissolved in 20 ml of ethanol was charged 20 ml of an 8% sodium hydroxide solution, and the mixture was refluxed for one hour. After removal of the ethanol under a reduced pressure, the residue was extracted with ether and separated by silica gel column chromatography (ethyl acetate:hexane=1:3) to give 5.13 g of the desired product (yield 89.9%).

Provenance & Evidence