1,3-Dimethyl-2-imidazolidinone → HCID 136331481, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5.0 g of p-aminoacetophenone. 6.6 g of ethyl orthoformate, 5 ml of 1,3-dimethyl-2-imidazolidinone and 0.03 g of concentrated sulfuric acid was placed in a reactor equipped with Dean's stark tube and agitated at 140° C. for about 10 minutes, followed by further addition of 5.8 g of nitroiminoimidazolidine and agitation at 160° C. for 1 hour. The reaction mixture was poured into 200 ml of a saturated saline solution, to which 150 ml of ethyl acetate was added. The resultant crystals were collected by filtration, and dried to give 5.4 g of 1-(4-methylcarbonyl-phenyliminomethyl)-2-nitroiminoimidazolidine.

Provenance & Evidence