Benzocaine → HCID 136331486, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 10.0 g of ethyl p-aminobenzoate, 10.8 g of ethyl orthoformate, 10 ml of 1,3-dimethyl-2-imidazolidinone and 0.05 g of boron trifluoride ether complex was placed in a reactor equipped with Dean's stark tube and agitated at 140° C. for about 5 minutes, followed by further addition of 7.9 g of nitroiminoimidazolidine and agitation at 180° C. for 1 hour. The reaction mixture was poured into 200 ml of a saturated saline solution, to which 150 ml of ethyl acetate was added. The resultant crystals were collected by filtration and dried to give 12.3 g of 1-(4-ethoxy-carbonylphenyliminomethyl)-2-nitroiminoimidazolidine.

Provenance & Evidence